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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well bring about an increase in methadone plasma concentrations, which could result in probably deadly respiratory melancholy. Also, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also result in a ri